UNESCO Chair in Bioethics

Contact

  • Bioethics and Law Observatory
  • UNESCO Chair in Bioethics
  • University of Barcelona
  • Faculty of Law
  • Ave. Diagonal, 684
  • 08034 Barcelona
  • (+34) 93 403 45 46
  • obd.ub@ub.edu
  •  
  • Master in Bioethics and Law
  • (+34) 93 403 45 46
  • master.bd@ub.edu

 

"Live birth of chimeric monkey with high contribution from embryonic stem cells"

Cell Press

A formal demonstration that mammalian pluripotent stem cells possess preimplantation embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early embryo complementation with homologous cells. Whereas such naive pluripotency has been well demonstrated in rodents, poor chimerism has been achieved in other species including non-human primates due to the inability of the donor cells to match the developmental state of the host embryos. Here, we have systematically tested various culture conditions for establishing monkey naive embryonic stem cells and optimized the procedures for chimeric embryo culture.